HYPOXIA-ALTERED CHOLESTEROL HOMEOSTASIS ENHANCES THE EXPRESSION OF INTERFERON-STIMULATED GENES UPON SARS-COV-2 INFECTIONS IN MONOCYTES

Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes

Hypoxia contributes to numerous pathophysiological conditions including inflammation-associated diseases.We characterized the impact of hypoxia on the immunometabolic cross-talk between cholesterol and interferon (IFN) responses.Specifically, hypoxia reduced cholesterol biosynthesis flux and provoked a compensatory activation of sterol regulatory e

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Effect of Educational Attainment on Health-Seeking Behaviour of Urban Slum Dwellers in Nigeria: An Insight from the Lagos State Metropolis in Nigeria

Background This research investigates the effect of socioeconomic correlates of educational attainment on the health-seeking behaviour of slum dwellers of the Lagos State metropolis.Methods Research locations were Ajeromi-Ifelodun, Apapa, Shomolu, and Lagos Mainland, which Novelty Teas are Local Government Areas that account for most of the notable

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Process design and feasibility study of food-grade salt production from crude solar salt in Madura, Indonesia

The production of food-grade salt from crude solar salt has been examined through a techno-economic evaluation.This study aimed to investigate a salt factory to analyze its technical and economic aspects to determine the HANDLES precise parameters for improving the quality of food-grade salt.The primary process of this factory involves grinding, wa

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Merging Sequence Optimization Based on Reverse Auction Theory and Merging Strategy with Active Trajectory Adjustment of Heterogeneous Vehicles

This paper investigates the optimized merging sequence (MS) and on-ramp merging strategy in mixed traffic with vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I).To this Sega CD end, a cooperative merging sequence optimization method is first proposed based on the reverse auction.In the method, a hybrid optimized computing structure is pr

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